This study has been carried out with the aim of studying the relationship between spiritual wellness and self-efficacy of students. Research method was descriptive and co. relational. Participants of research consisted of 400 male and female students of bachelor’s degree of the faculty of psychology and educational sciences and engineering of Sistan-va-Baloochestan University. A total of 190 students were selected according to  Morgan table based on stratified random sampling. Paloutzian & Ellison Spiritual Well-being Questionnaire (1982) and Sherrer et al. Self-efficacy Questionnaire (1982) were used to gather information. The obtained information was assessed according to Pierson correlation coefficient and stepwise regression. Results of study showed that there was a significant correlation between spiritual well-being and self-efficacy. Results of stepwise regression analysis indicated that as one of the subscales of spiritual health, physical health was the best predictor of students’ self-efficacy. Moreover, results of independent test showed that the spiritual well-being was higher in girls than boys. No significant difference was observed between male and female students with regard to self-efficacy. Regarding the type of faculty a significant difference was observed between spiritual well-being and self-efficacy. Students of faculty of educational sciences and psychology had a higher mean. As regards the status of residence, no significant difference was observed between spiritual well-being and self-efficacy of students.